The Weight of Blood

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DescriptionThis is the second edition of a comprehensive book on the research into the link between diabetes and obesity. Divided into two sections, it is an in-depth examination of the multiple factors that drive obesity and how those factors may be prevalent in the development of diabetes. This second edition also focuses on the role of diet in both populations and how nutrition may be linked to the pathogenesis of obesity and diabetes. Supporting research provides emerging treatment approaches and disease management therapies. The first edition was published almost a decade ago.PurposeThe purpose is to provide a unique forum that highlights the link between obesity and diabetes. From the introduction, it is apparent that the authors are passionate about their knowledge and research in this area and how these disorders have come to be recognized as burdens to both individuals who have obesity or diabetes and to society in general. As the incidence of obesity rises, the incidence of type 2 diabetes is also rising. The purpose of this book is to better understand these diseases in order to better treat individuals afflicted with them. The authors' purpose is also to highlight the links between these two disease states; specifically, the underlying mechanisms of how each develops, the epidemiology, pathogenesis, and treatment, and the underlying nutritional relationship to each of these diseases. Despite current efforts, the incidence of obesity and diabetes continues to rise, even among children. As more research has come out in the past decade on both topics, it has become imperative to begin treating these diseases in a different manner, first by understanding how they develop and, second, by understanding their connection to one another. The authors have brought together a wide array of professionals to write the 24 chapters on the relationship of diabetes and obesity and the role of nutrition in the pathogenesis of obesity and diabetes. The information this book collects provides emerging therapeutic approaches formanaging these diseases. AudienceThe audience includes physicians, dietitians, nutritionists, and other healthcare professionals who have daily interactions with persons who have obesity and diabetes. This book is also for researchers who desire a deeper understanding or want to identify gaps in our current knowledge of these diseases. The authors state that this book also would be of interest to experts and officials involved in making healthcare policies, and members of the general population (especially those with obesity and/or diabetes) who wish to learn more about these diseases. The authors of each chapter are highly regarded as experts in their fields and come from a variety of background settings. FeaturesThis book examines the various factors that drive the development of obesity, the metabolic adaptations of obesity, and how this can lead to the development of obesity with diabetes. The role of nutrition is highlighted in the pathogenesis of obesity and diabetes. This book is clearly organized into two easy to understand sections -- the first focuses on the pathophysiology and treatment of obesity and the second on the pathophysiology and treatment of diabetes. Both sections are well written, well researched, and well organized. Topics in both sections include some previously known research, such as genetic determinants of obesity and diabetes, as well as diet and physical activity, but this book also highlights new interventions and newer therapies. The book begins with a look into modulators of appetite and satiety. This information is crucial for healthcare professional working with a population of patients who have obesity, as this disease has far more underlying mechanisms of action than previously recognized. The information on the gut microbiota and how it may impact both the development and treatment of obesity and diabetes is exciting and contemporary, but not well understood by many current professionals. The book also highlights treatment modalities such as pharmacotherapy and bariatric surgery for persons with obesity as well as diabetes. These subjects may often be overlooked by practitioners, and it is imperative to include information on these subjects when discussing obesity and diabetes. Not only does this book focus on pathophysiology and treatment methods, it combines several chapters regarding nutrition in the pathophysiology and treatment of obesity and diabetes. However, given the title of the book, more information regarding current nutrition practices or emerging nutrition practices for obesity (coverage of specific diets and recommendations) may have made a stronger case for nutrition as a treatment modality.AssessmentThe intended audience (healthcare professionals, researchers, policy makers and general patient populations) will find this book extremely useful. The information in this updated edition provides an in-depth, easy to understand look at how obesity and diabetes develop. This is extremely important for healthcare practitioners who may work with a population of patients who have obesity and/or diabetes and are struggling to understand their patients or are seeking new and more effective treatment options. Anyone in the general population who has obesity and/or diabetes also would find this book useful in better understanding their disease and how or why it has developed. After reading this book, patients also may have a better understanding of the treatment advice their healthcare team provides. This second edition is warranted and needed; as researchers have discovered new and exciting information on the epidemiology, pathogenesis, and treatment of diabetes and obesity, many healthcare practitioners, researchers, policymakers and patients have come to think about these diseases differently than a decade ago. As we have found more effective treatment methods for these diseases, it is imperative to provide this information to those who treat, assess, or live with obesity and/ or diabetes- Holly Herrington, MS, RD (Northwestern Memorial Hospital)

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‘Developability of Biotherapeutics: Computational Approaches presents the most extensive and systematic overview to date, of modern computational approaches that are being used industrially to assess potential manufacturability and overall ease of development of biotherapeutics such as monoclonal antibodies.  The book covers a wide array of topics, spanning from immunogenicity and pharmacokinetic/dynamic properties to key chemical and physical stability attributes.  It is recommended as important reading for researchers from both academic and industrial perspectives, and will be of particular interest for graduate students seeking to gain an experienced perspective of the current state of the art and opportunities for high impact research in the future’.– Christopher J. Roberts, Professor of Chemical & Biomolecular Engineering, University of Delaware.'Developability of Biotherapeutics: computational approaches presents a state-of-the art and modern overview on computational approaches for evaluating developability of biotherapeutics. Optimal molecule design and selection is a yet underappreciated and underutilized element of finding, developing, and finally commercializing the best molecule. The optimum molecule not only serves patient needs by ensuring efficacy and safety, but is also optimized from a technical drug product development perspective. This book is a must-read for industrial and academic researchers involved in discovering, identifying and optimizing molecules and transitioning from research to development and beyond.' – Prof. Dr. Hanns-Christian Mahler,Head of Drug Product Services, Lonza AG.‘This book represents a compelling opening salvo to the field of computational methods applied to antibody developability. The chapters are… supported by extensive and timely literature citations: the average number of citations per chapter goes above 90, with over 50% of the references dating to 2009 or later. Developability of Biotherapeutics: Computational Approaches should be a good addition to the libraries of industrial and academic groups engaged in, or supporting, development of biopharmaceutical drugs.’– Charlotte M. Deane & Maximiliano Vásquez (2016), mAbs, DOI: 10.1080/19420862.2016.1256723.

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"In Fundamentals of Glacier Dynamics, Kees van der Veen guides the reader with ease through the different, and sometimes complex, aspects of glacier mechanics. Compared to the first edition, this second revised edition is definitely more focused on ice-dynamical concepts and explains comprehensively the mathematical derivation of stress tensors, deviatoric stresses, invariants, flow laws, glacier and ice stream flow, etc."—Frank Pattyn, Laboratoire de Glaciologie, Université Libre de Bruxelles, Belgium"A detailed and timely introduction to the flow and dynamics of glaciers and ice sheets. It will provide excellent guidance to scientists and graduate students for interpreting and modelling the ongoing dramatic changes of alpine and polar ice masses. An impressive book that will stay lie open on my desk."—Andreas Vieli, Department of Geography, Durham University, UK"Fundamentals of Glacier Dynamics by Kees van der Veen proceeds logically through the list of topics necessary for a beginning graduate or upper-level undergraduate student to build a strong foundation in glacier dynamics. … Excellent derivations and descriptions are given for the various "end member" models of ice flow … . For students and professionals alike, [this book] serves as a detailed introduction to quantitative glaciology, a reference volume, and an essential companion to Paterson’s classic Physics of Glaciers."—Stephen Price, Fluid Dynamics and Solid Mechanics Group, Los Alamos National Laboratory
"There is a small and select collection of manuscripts that I keep within arms reach of my desk and this book is one of them. It has a unique place in the catalogue of glaciological texts, providing a thorough treatise on the principles and governing equations that underpin our understanding of ice motion and thermodynamics. … An essential reference text for glaciologists concerned about the flow of ice."—Jonathan Bamber, Bristol Glaciology Centre, School of Geographical Sciences, University of Bristol, UK"For years, I have been reaching for C.J. van der Veen 's Fundamentals of Glacier Dynamics when I need substantive and mathematical discussion of ice dynamics. The detailed treatments in the text are ably guided by van der Veen's clear thinking about the fundamentals such as the partitioning of stresses, the energy budget, equilibrium profiles, and the global significance of ice dynamics. Indeed, these fundamentals provide the reader a trail of bread crumbs to guide them through the forest of details that constitute modern glaciology. Now in its second edition, and expanded to include topics such as fracture, I expect that Fundamentals of Glacier Dynamics will continue to be the first text I consult, as well as the one I recommend to students.""—Jesse Johnson, The University of Montana, USA
"As previously, [this second edition] provides an excellent introduction to glacier and ice sheet dynamics. Being essentially self-contained, it appeals to students from undergraduate to postgraduate level as well as to researchers, both from within the field and from neighboring disciplines. It is indeed an excellent textbook, which I have used a lot when teaching ice dynamics ... [It will] surely be one of the fixed points in the treatments of ice dynamics in the decades to come."—Nina Kirchner, Stockholm University, Sweden
Praise for the First Edition
"Until now, there has been a growing gap between the relatively introductory treatment of glacier dynamic modeling found in standard texts on glaciology and the large body of research literature. Van der Veen's book does a wonderful service by supplying an approachable, but comprehensive bridge. ... There have been several recent books on glaciers and glacial dynamics and this one is a standout. For any worker who is contemplating modeling or who has to deal with the output of models, this is must have book."—Neil Humphrey, Department of Geology and Geophysics, University of Wyoming Laramie, USA, Arctic, Antarctic, and Alpine Research, Vol. 34, No. 3, Aug. 2002
"... does an excellent job of presenting our current understanding. ... The back cover recommends the book as suitable for graduate courses in geophysics, and I would endorse this. In addition, it is an excellent refresher for someone like myself who has long experience in glaciology but has read only some of the more recent papers. The author has distilled most of these papers into a very readable volume. ... I see this book as the best of the mathematical bunch, and I would strongly recommend it to established and aspiring glaciologists and to those from other disciplines eager to know just how well—or perhaps how poorly—we understand glaciers and ice sheets."—Robert H. Thomas, EG&G Services, NASA/Wallops, Wallops Island, Virginia, USA, Eos, Vol. 82, No. 1, Jan. 2, 2001
"What I particularly liked about the book were some fine passages of critical discussion which look at the relationship between theory and observations in some controversial areas. ... It is a better book for people who want to use glaciological theory than either Paterson’s book or Hooke’s book. ... It contains a pretty complete description of ice–climate interactions which is better than anything else in press. If your primary interest is in ice–climate interactions, it would be your best choice as first textbook."—Richard Hindmarsh, British Antarctic Survey, Cambridge, Earth Surface Processes and Landforms, 26, 2001
"If Paterson’s classic text The physics of glaciers may be considered a bible of modern glaciology, then this recent book by Kees van der Veen is probably one of the newly unearthed gospels. ... Van der Veen is also quite successful at getting across the philosophy of mathematical modelling. ... if your main interest is to acquire the skills to model glacier motion, this book should certainly be high on your shopping list. The more experienced researcher will also find it useful as a reference and teaching aid."—Felix S.L. Ng, Mathematical Institute, University of Oxford, UK, Journal of Glaciology, Vol. 46, No. 155, 2000
"... this book is best seen as a practical, users' guide to developing the equations and models that describe the physical behaviour of ice masses. As such, it serves as an excellent reference text both to glaciologists and, equally important, to scientists outside the discipline who may wish to familiarise themselves with state-of-the-art numerical glaciology. Topics and treatments are introduced from their fundamental principles and developed quantitatively at a level that can be followed by readers with mathematics or physics to undergraduate level. ... Fundamentals of glacier dynamics is a well-written and well-produced text which is fair value. ... To summarise, this is a very useful book to those with some mathematical ability and who have an interest in the quantitative description and modelling of ice dynamics."—Bryn Hubbard, Polar Record, Vol. 36, Issue 199, October 2000

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The Weight of Blood

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